Isaac Franklin (May 26, 1789 – April 27, 1846) was an American slave trader and plantation owner. He was the co-founder of Franklin & Armfield, which became the largest slave trading firm in the United States. Based in Alexandria, Virginia, it also had offices in New Orleans and other Louisiana cities. Franklin owned six plantations in Louisiana and Tennessee. His Fairvue plantation, in Sumner County, Tennessee, was formerly listed on the National Register of Historic Places.