Isesaki Domain (伊勢崎藩, Isesaki-han) was a feudal domain under the Tokugawa shogunate of Edo period Japan, located in Kōzuke Province (modern-day Gunma Prefecture), Japan. It was centered on Isesaki jin'ya in what is now part of the city of Isesaki, Gunma. Isesaki was ruled through most of its history by a junior branch of the Sakai clan.