Iyo-Matsuyama Domain (伊予松山藩, Iyo-Matsuyama-han) was a feudal domain under the Tokugawa shogunate of Edo period Japan, in what is now central Ehime Prefecture on the island of Shikoku. It was centered around Matsuyama Castle, and was ruled throughout most of its history by the shinpan daimyō Hisamatsu-Matsudaira clan. Iyo-Matsuyama Domain was dissolved in the abolition of the han system in 1871 and is now part of Ehime Prefecture.