James S. Hyde (May 20, 1932 - August 13, 2022) was an American biophysicist. He held the James S. Hyde chair in Biophysics at the Medical College of Wisconsin (MCW) where he specialized in magnetic resonance instrumentation and methodology development in two distinct areas: electron paramagnetic resonance (EPR) spectroscopy and magnetic resonance imaging (MRI). He is senior author of the widely cited 1995 paper by B.B. Biswal et al. reporting the discovery of resting state functional connectivity (fcMRI) in the human brain. He also served as Director of the National Biomedical EPR Center, a Research Resource supported by the National Institutes of Health. He was author of more than 400 peer-reviewed papers and review articles and held 35 U.S. Patents. He was recognized by Festschrifts in b
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