Manase Jesse Sapolu (born March 10, 1961) is a Samoan former American football player in the National Football League. He played both center and offensive guard, and played his entire career for the San Francisco 49ers. Sapolu attended Farrington High School and the University of Hawaii in Honolulu. Standing 6 feet 4 inches, 278 lbs., he was selected by the Oakland Invaders in the 17th round (199th pick overall) of the 1983 USFL Draft, and selected by San Francisco 49ers in the 11th round (289th pick overall) of the 1983 NFL Draft. He signed with the San Francisco 49ers on July 10, 1983.