Kentucky Route 15 begins at a junction of US 119/Corridor F & Business KY 15 in Whitesburg, and terminates in Winchester at US 60. It is a major route, connecting the coalfields of the Cumberland Plateau with Lexington and other cities in the Bluegrass region. The segment from Whitesburg to KY 15 at Campton, which in turn connects to the Bert T. Combs Mountain Parkway near the town, is also the primary part of Corridor I of the Appalachian Development Highway System.