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The L-type calcium channel (also known as the dihydropyridine channel, or DHP channel) is part of the high-voltage activated family of voltage-dependent calcium channel."L" stands for long-lasting referring to the length of activation. This channel has four isoforms: Cav1.1, Cav1.2, Cav1.3, and Cav1.4. L-type calcium channel blocker drugs are used as cardiac antiarrhythmics or antihypertensives, depending on whether the drugs have higher affinity for the heart (the phenylalkylamines, like verapamil), or for the blood vessels (the dihydropyridines, like nifedipine).

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rdf:type
rdfs:label
  • قناة الكالسيوم نوع L (ar)
  • Courant calcique de type L (fr)
  • L-type calcium channel (en)
  • Canale del calcio di tipo L (it)
  • L-type-calciumkanaal (nl)
  • Canal de cálcio do tipo L (pt)
  • L型钙通道 (zh)
rdfs:comment
  • O canal de cálcio do tipo L é um tipo de canal de cálcio dependente de voltagem. tal como em outros da sua classe, a subunidade α1 é aquela que determina a maioria das propriedades do canal. Drogas bloqueadoras do canal de cálcio do tipo L, são usadas como antiarrítmicos cardíacos ou anti-hipertensivos, dependendo se a droga tem maior afinidade ao coração ou para os vasos. Estes canais do tipo L são bloqueados selectivamente por , como o diltiazem. (pt)
  • L-型钙通道(英文:L-type calcium channel)是一种的类型钙通道。“L”为“long-lasting”的首字母,表示激活状态的时间持久。和其他同类钙通道一样,α1亚基是决定其主要性质的部分。此通道允许通过钙离子产生L型钙电流,可见于心房、心室和蒲肯野纤维的动作电位第2时相。 作用于L-型钙通道的药物可被用作抗心律失常药和抗高血压药。 (zh)
  • قناة الكالسيوم نوع L (وتعرف كذلك باسم قناة ثنائي هيدرو البيريدين، أو قناة DHP) هي جزء من عائلة المنشَّطة بفولتية عالية. يشير حرف "L" إلى Long-lasting أي طويلة الأمد وهي مدة تنشيط هذا النوع من القنوات. يملك هذا النوع من القنوات أربع وحدات فرعية ( ، ، ) قناة الكالسيوم من النوع L مسؤولة على تقارن الاستثارة والتقلص الخاص بالعضلة القلبية والهيكلية والملساء وعلى إفراز الألدوستيرون في الغدة الصماء وقشرة الكظرية. (ar)
  • The L-type calcium channel (also known as the dihydropyridine channel, or DHP channel) is part of the high-voltage activated family of voltage-dependent calcium channel."L" stands for long-lasting referring to the length of activation. This channel has four isoforms: Cav1.1, Cav1.2, Cav1.3, and Cav1.4. L-type calcium channel blocker drugs are used as cardiac antiarrhythmics or antihypertensives, depending on whether the drugs have higher affinity for the heart (the phenylalkylamines, like verapamil), or for the blood vessels (the dihydropyridines, like nifedipine). (en)
  • Le courant ionique de type L est un courant calcique à "charge longue" (en anglais long lasting). Il s'inactive lentement. Il est impliqué dans la génération de potentiel d'action dans les dendrites et dans la transmission synaptique. On retrouve 4 protéines-canal capable de générer ce courant ionique: Cav1.1 (majoritairement dans les muscles squelettiques), Cav1.2 (les muscles cardiaques, les muscles lisses, glande pituitaire, et les glandes surrénales), Cav1.3 (cerveau, pancréas, rein, ovaires et cochlée), Cav1.4 (dans la rétine). (fr)
  • Il canale del calcio di tipo L è un tipo di canale del Ca++ voltaggio-dipendente. "L" sta per long lasting, ovvero duraturo in riferimento alla lunghezza dell'attivazione.I canali del calcio di tipo L sono responsabili della normale contrattilità del miocardio e della muscolatura liscia vascolare. Il canale di tipo L è costituito da cinque subunità: subunità alfa-1, alfa-2, beta, gamma e delta.Come per le altre proteine di questa classe, la subunità α1 è quella che determina la maggior parte delle proprietà del canale, oltre a essere il sito di legame per i calcio antagonisti. Questo canale si apre lasciando che un flusso di calcio lo attraversi portandosi all'interno della cellula. Una volta aperti questi canali si richiudono con lentezza e forniscono un flusso di Ca++ che perdura nel tem (it)
  • Het L-type-calciumkanaal is een subtype van de voltage-gereguleerde calciumkanalen. De letter L staat voor de lange duur van de activatie van dit kanaal. L-type-calciumkanalen komen onder andere voor in spiercellen en in neuronen. Het centrale onderdeel van deze kanalen, de α subunit, wordt gecodeerd door genen uit de CACNA1-familie. (nl)
rdfs:seeAlso
name
  • Calcium channel, voltage-dependent (en)
foaf:depiction
  • http://commons.wikimedia.org/wiki/Special:FilePath/L-type_D-subtype_CaV1.3_calcium_channel_CACNA1D_in_human_adrenal_zona_glomerulosa.jpg
  • http://commons.wikimedia.org/wiki/Special:FilePath/General_L-type_calcium_channel.jpg
  • http://commons.wikimedia.org/wiki/Special:FilePath/L-type_calcium_channel_3JBR.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/Alphasubunit_sodium_channel.png
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