About: Leonard R. Stephens

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Leonard (Len) R Stephens FRS (born 18 June 1960) is a molecular biologist, senior group leader and associate director at the Babraham Institute. Len Stephens has contributed much to the understanding of inositol lipids functions in eukaryotic cells, and in particular in neutrophils. Early highlights were the mapping of new pathways of inositol phosphate synthesis.Together with his long-time collaborator Phillip Thomas Hawkins, he established that PtdIns(4,5)P2 is the main substrate of receptor-controlled Type 1 phosphoinositide 3-kinases (PI3Ks), thus identifying PtdIns(3,4,5)P3 as the key output signal produced by this enzyme.They identified and isolated the GPCR-activated Type 1B PI3K (PI3KΥ) and, in a sustained body of work, defined its structure, explained its complex pattern of regula

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rdf:type	Thing foaf:Person person dul:NaturalPerson Eukaryote Person Human Animal yago:WikicatBritishScientists animal eukaryote scientist species schema:Person yago:WikicatLivingPeople Scientist yago:Academician109759069 yago:Adult109605289 yago:CausalAgent100007347 yago:Educator110045713 yago:LivingThing100004258 yago:Object100002684 yago:Organism100004475 yago:Person100007846 yago:PhysicalEntity100001930 yago:Professional110480253 yago:YagoLegalActor yago:YagoLegalActorGeo yago:Scientist110560637 yago:Whole100003553 yago:WikicatAcademicsOfTheUniversityOfCambridge
rdfs:label	ليونارد ر. ستيفنز (ar) Leonard R. Stephens (en)
rdfs:comment	ليونارد ر. ستيفنز (بالإنجليزية: Leonard R. Stephens)‏ هو أحيائي بريطاني، ولد في 18 يونيو 1960. (ar) Leonard (Len) R Stephens FRS (born 18 June 1960) is a molecular biologist, senior group leader and associate director at the Babraham Institute. Len Stephens has contributed much to the understanding of inositol lipids functions in eukaryotic cells, and in particular in neutrophils. Early highlights were the mapping of new pathways of inositol phosphate synthesis.Together with his long-time collaborator Phillip Thomas Hawkins, he established that PtdIns(4,5)P2 is the main substrate of receptor-controlled Type 1 phosphoinositide 3-kinases (PI3Ks), thus identifying PtdIns(3,4,5)P3 as the key output signal produced by this enzyme.They identified and isolated the GPCR-activated Type 1B PI3K (PI3KΥ) and, in a sustained body of work, defined its structure, explained its complex pattern of regula (en)
foaf:name	Len Stephens (en)
name	Len Stephens (en)
dcterms:subject	1960 births Living people Academics of the University of Cambridge Alumni of the University of Birmingham Fellows of the Royal Society Members of the European Molecular Biology Organization British molecular biologists
Wikipage page ID	41644229 (xsd:integer)
Wikipage revision ID	1088868156 (xsd:integer)
Link from a Wikipage to another Wikipage	European Molecular Biology Organisation Biology University of Birmingham Inflammation 1960 births Living people GPCR Phosphatidylinositol 3,4,5-trisphosphate Phosphoinositide 3-kinases Phosphoinositide-dependent kinase-1 Protein kinase B BSc Babraham Institute Academics of the University of Cambridge Alumni of the University of Birmingham Fellows of the Royal Society UK Dario Alessi Cell proliferation Ras subfamily Members of the European Molecular Biology Organization British molecular biologists Signal transduction Phosphatidylinositol 4,5-bisphosphate Physiology PhD Fellow of the Royal Society of London Immunology Phillip Thomas Hawkins Neutrophil granulocyte Molecular biologist Inositol lipids and phosphate
Link from a Wikipage to an external page	http://www.babraham.ac.uk/our-research/signalling/stephens/
sameAs	Leonard R. Stephens Leonard R. Stephens Leonard R. Stephens Leonard R. Stephens Leonard R. Stephens Leonard R. Stephens
work institutions	Babraham Institute
dbp:wikiPageUsesTemplate	dbt:Authority_control dbt:Reflist dbt:Use_dmy_dates dbt:Infobox_scientist dbt:FRS_2011
alma mater	University of Birmingham
field	Signal transduction Immunology
nationality	UK
residence	UK
has abstract	ليونارد ر. ستيفنز (بالإنجليزية: Leonard R. Stephens)‏ هو أحيائي بريطاني، ولد في 18 يونيو 1960. (ar) Leonard (Len) R Stephens FRS (born 18 June 1960) is a molecular biologist, senior group leader and associate director at the Babraham Institute. Len Stephens has contributed much to the understanding of inositol lipids functions in eukaryotic cells, and in particular in neutrophils. Early highlights were the mapping of new pathways of inositol phosphate synthesis.Together with his long-time collaborator Phillip Thomas Hawkins, he established that PtdIns(4,5)P2 is the main substrate of receptor-controlled Type 1 phosphoinositide 3-kinases (PI3Ks), thus identifying PtdIns(3,4,5)P3 as the key output signal produced by this enzyme.They identified and isolated the GPCR-activated Type 1B PI3K (PI3KΥ) and, in a sustained body of work, defined its structure, explained its complex pattern of regulation by GβΥ and Ras, and proved its role in inflammatory events in vivo.They – in parallel with Dario Alessi – identified phosphoinositide-dependent kinase-1 as the PtdIns(3,4,5)P3-activated link between PI3K-1 activation and protein kinase B activation, a key pathway through which PtdIns(3,4,5)P3 formation regulates cell proliferation and survival. Later, they showed that PtdIns(3,4,5)P3 was responsible for the recruitment of both PKB and PDK1 to the membrane, and therefore the activation of the former by the latter. (en)
gold:hypernym	Biologist
prov:wasDerivedFrom	wikipedia-en:Leonard_R._Stephens?oldid=1088868156&ns=0

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