The Lick Skillet Railroad Work Station Historic District is a historic district in Brinkley, Arkansas that was listed on the National Register of Historic Places in 1992. It includes the former Brinkley Union Station located at the site of the former crossing of the Rock Island and Cotton Belt railroads in Brinkley, Monroe County in eastern Arkansas. In addition to the Rock Island and Cotton Belt, the station also served branchline trains of the Missouri Pacific. It also includes Rusher Hotel, also known as Great Southern Hotel.