Lucile Eleanor St. Hoyme (September 8, 1924 – November 15, 2001) was an American biological anthropologist who conducted research related to human variation, bioarcheology, and paleopathology. St. Hoyme served as an Assistant Curator in the Department of Anthropology at the National Museum of Natural History. St. Hoyme analyzed human remains excavated from the John Kerr (Buggs Island, Virginia) Reservoir Basin using a new bioarcheological approach combining data from other disciplines. Beyond her work with the Smithsonian collections, St. Hoyme also worked on FBI forensic cases in the 1960s with National Museum of Natural History Anthropology Curator J. Lawrence Angel.