About: MT-45

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MT-45 (IC-6) is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative, which is structurally unrelated to most other opioid drugs. Racemic MT-45 has around 80% the potency of morphine, with almost all opioid activity residing in the (S) enantiomer (the opposite stereochemistry from the related drug lefetamine). It has been used as a lead compound from which a large family of potent opioid drugs have been developed, including full agonists, partial agonists, and antagonists at the three main opioid receptor subtypes. Fluorinated derivatives of MT-45 such as 2F-MT-45 are significantly more potent as μ-opioid receptor agonists, and one of its main metabolites 1,2-diphenylethylpiperazine also b

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug yago:Agent114778436 yago:CausalAgent100007347 yago:Drug103247620 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 yago:Piperazine103946814 drug yago:Substance100020090 yago:Vermifuge104528630 yago:WikicatPiperazines
rdfs:label	MT-45 (en)
rdfs:comment	MT-45 (IC-6) is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative, which is structurally unrelated to most other opioid drugs. Racemic MT-45 has around 80% the potency of morphine, with almost all opioid activity residing in the (S) enantiomer (the opposite stereochemistry from the related drug lefetamine). It has been used as a lead compound from which a large family of potent opioid drugs have been developed, including full agonists, partial agonists, and antagonists at the three main opioid receptor subtypes. Fluorinated derivatives of MT-45 such as 2F-MT-45 are significantly more potent as μ-opioid receptor agonists, and one of its main metabolites 1,2-diphenylethylpiperazine also b (en)
foaf:depiction
dcterms:subject	Designer drugs Mu-opioid receptor agonists Cyclohexylamines Synthetic opioids Diphenylethylpiperazines
Wikipage page ID	31291294 (xsd:integer)
Wikipage revision ID	1086155690 (xsd:integer)
Link from a Wikipage to another Wikipage	Cataracts Dermatitis Remacemide Alopecia Designer drugs Mu-opioid receptor agonists Oral administration Overdose Opioid receptor Ephenidine Morphine Controlled Drugs and Substances Act Lefetamine Hearing loss Lead compound AD-1211 AH-7921 Analgesic Fluorolintane Cyclohexylamines Synthetic opioids Health Canada Μ-opioid receptor AP-238 Diphenylethylpiperazines Lanicemine Rectal administration Diphenidine Diphenpipenol Piperazine IC-26 Methoxphenidine Metonitazene Opioid NMDA receptor Mees lines Triparanol Dainippon Pharmaceutical Co.
Link from a Wikipage to an external page	https://pubchem.ncbi.nlm.nih.gov/compound/132990975
sameAs	MT-45 MT-45 MT-45 MT-45 MT-45 MT-45 MT-45
dbp:wikiPageUsesTemplate	dbt:Clear-left dbt:Drugbox dbt:Opioidergics dbt:Piperazines dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Fdacite dbt:Stdinchicite
thumbnail	wiki-commons:Special:FilePath/MT-45_svg.svg?width=300
ATC prefix	None (en)
c	24 (xsd:integer)
CAS number	52694 (xsd:integer)
CAS supplemental	52694 (xsd:integer)
ChemSpiderID	381935 (xsd:integer)
H	32 (xsd:integer)
IUPAC name	1 (xsd:integer)
legal DE	Anlage II (en)
legal UK	Class A (en)
legal US	Schedule I (en)
n	2 (xsd:integer)
PubChem	431865 (xsd:integer)
routes of administration	Oral administration Rectal administration
SMILES	c3ccccc3CCNCCN1C4CCCCC4 (en)

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