State Route 220 (SR 220) is a state highway located in central coastal Maine. It begins at State Route 97 in Friendship on the Atlantic coast and runs for 66.50 miles (107.02 km) north to Palmyra, where it ends at State Route 11 and State Route 100. SR 220 runs through a series of small towns, with connecting routes leading to larger population centers such as Augusta, Waterville, and Bangor to the east and west.