María de la Ossa de Amador (2 March 1855 – 5 July 1948) was the inaugural First Lady of Panama serving from February 1904 to October 1908. She was one of the creators of the original Panamanian flag and a member of the separatist movement which fought for Panamanian independence from Colombia. She is known as the "Mother of the Nation" and in the corregimiento Parque Lefevre a school was named in her honor. In 1953, for the nation's 50th anniversary, a stamp bearing the likeness of her and her husband was issued by the government of Panama.