Mathilde of Hesse (4 July 1473 in Blankenstein – 19 February 1505 in Cologne) was a Landrave princess from birth and became the Duchess of Cleves and Countess of La Marck through her marriage to John II, Duke of Cleves in 1489 until her death. She was the daughter of Henry III, Landgrave of Upper Hesse (1441-1483) and his wife Anna of Katzenelnbogen (1443-1494).She is notable for being the grandmother to Anne of Cleves the fourth wife of King Henry VIII of England.