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About: Matrix-core     Goto   Sponge   NotDistinct   Permalink

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The matrix-core theory of thalamus, first proposed by Ted Jones, states that neurons in the thalamus belong to either a calbindin-immunopositive matrix of diffusely and widely projecting neurons, or to a parvalbumin-immunopositive core of precisely projecting neurons. Unfortunately only one nuclei is simply immunoreactive to just one of three calcium binding proteins, and that is the centromedial nuclei which stains for parvalbumin. A given region usually stains for two of the three proteins—parvalbumin, calbindin, and calretinin The neurons comprising the core are believed to be involved in propagation of 'driving' information, whereas neurons comprising the matrix are believed to play a more modulatory role.