About: Mecasermin

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Mecasermin, sold under the brand name Increlex, also known as recombinant human insulin-like growth factor-1 (rhIGF-1), is a recombinant form of human insulin-like growth factor 1 (IGF-I) which is used in the long-term treatment of growth failure and short stature in children with severe primary IGF-I deficiency, for instance due to growth hormone deficiency or Laron syndrome (growth hormone insensitivity). Mecasermin has a biological half-life of about 5.8 hours in children with severe primary IGF-1 deficiency.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug yago:Abstraction100002137 yago:BodySubstance105263850 yago:Hormone105407119 yago:LiquidBodySubstance105397468 yago:Matter100020827 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 yago:WikicatGrowthHormones drug protein yago:Secretion105404728 yago:Somatotropin105412649 yago:Substance100019613 umbel-rc:DrugProduct
rdfs:label	Mecasermina (it) Mecasermin (en)
rdfs:comment	Mecasermin, sold under the brand name Increlex, also known as recombinant human insulin-like growth factor-1 (rhIGF-1), is a recombinant form of human insulin-like growth factor 1 (IGF-I) which is used in the long-term treatment of growth failure and short stature in children with severe primary IGF-I deficiency, for instance due to growth hormone deficiency or Laron syndrome (growth hormone insensitivity). Mecasermin has a biological half-life of about 5.8 hours in children with severe primary IGF-1 deficiency. (en) Mecasermina (INN, nome commerciale Increlex) è un fattore di crescita insulino-simile (IGF-I) ricombinante umano, prodotto in Escherichia coli cioè in batteri che sono stati modificati mediante l’aggiunta del gene per l’IGF-1 umano. Il farmaco viene utilizzato per il trattamento a lungo termine del deficit di crescita nei bambini con deficit di IGF-I primario grave. (it)
dcterms:subject	Insulin-like growth factor receptor agonists Endocrinology Peptides Growth hormones Insulin receptor agonists
Wikipage page ID	16927504 (xsd:integer)
Wikipage revision ID	1091908664 (xsd:integer)
Link from a Wikipage to another Wikipage	Insulin-like growth factor receptor agonists dbr:Insulin-like_growth_factor_1 Mecasermin rinfabate Subcutaneous injection Endocrinology Recombinant DNA Peptides Growth hormones Laron syndrome Biological half-life Ternary complex Growth hormone Growth hormone deficiency Insulin receptor agonists Short stature Growth failure Insulin-like growth factor binding protein-3 Insulin-like growth factor binding protein acid labile subunit
Link from a Wikipage to an external page	https://druginfo.nlm.nih.gov/drugportal/name/mecasermin
sameAs	Mecasermin Mecasermin Mecasermin Mecasermin Mecasermin Mecasermin Mecasermin Mecasermin Mecasermin Mecasermin
dbp:wikiPageUsesTemplate	dbt:Cite_web dbt:Drugbox dbt:Portal_bar dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Keggcite dbt:Drugs.com dbt:Growth_factor_receptor_modulators dbt:Systemic-hormonal-drug-stub
ATC suffix	AC03 (en)
ATC prefix	H01 (en)
c	331 (xsd:integer)
CAS number	68562 (xsd:integer)
ChEMBL	1201716 (xsd:integer)
ChemSpiderID	none (en)
DrugBank	DB01277 (en)
elimination half-life	20880.0 (second)
H	512 (xsd:integer)
KEGG	D04870 (en)
legal US	Rx-only (en)
n	94 (xsd:integer)
O	101 (xsd:integer)
routes of administration	Subcutaneous injection
s	7 (xsd:integer)
synonyms	FK-780; Recombinant human insulin-like growth factor-1; rhIGF-1; Somatomedin-1 (en)
tradename	Increlex (en)
UNII	7 (xsd:integer)
Verifiedfields	changed (en)
verifiedrevid	462101108 (xsd:integer)
Watchedfields	changed (en)
has abstract	Mecasermin, sold under the brand name Increlex, also known as recombinant human insulin-like growth factor-1 (rhIGF-1), is a recombinant form of human insulin-like growth factor 1 (IGF-I) which is used in the long-term treatment of growth failure and short stature in children with severe primary IGF-I deficiency, for instance due to growth hormone deficiency or Laron syndrome (growth hormone insensitivity). Mecasermin has a biological half-life of about 5.8 hours in children with severe primary IGF-1 deficiency. A related medication is mecasermin rinfabate (brand name Iplex), which is a combination of mecasermin (rhIGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), and insulin-like growth factor binding protein acid labile subunit (IGFALS) as a ternary complex. The complex serves to prolong the action of mecasermin in the human body; the half-life of mecasermin when provided as this complex is 13.4 hours in individuals with severe primary IGF-1 deficiency. (en) Mecasermina (INN, nome commerciale Increlex) è un fattore di crescita insulino-simile (IGF-I) ricombinante umano, prodotto in Escherichia coli cioè in batteri che sono stati modificati mediante l’aggiunta del gene per l’IGF-1 umano. Il farmaco viene utilizzato per il trattamento a lungo termine del deficit di crescita nei bambini con deficit di IGF-I primario grave. Questo farmaco non deve essere confuso con mecasermina rinfabato (nome commerciale Iplex), che è una combinazione di ricombinante IGF-1 (rhIGF-1) umano e del fattore di crescita insulino-simile binding protein-3 (-3). L'IGFBP-3 serve per prolungare l'azione dell'IGF-1 nel corpo umano. (it)
legal AU	S4 (en)
legal CA	Rx-only / Schedule D (en)
licence EU	yes (en)
pregnancy AU	B3 (en)
gold:hypernym	Factor

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