Meesmann corneal dystrophy (MECD) is a rare hereditary autosomal dominant disease that is characterized as a type of corneal dystrophy and a keratin disease. MECD is characterized by the formation of microcysts in the outermost layer of the cornea, known as the anterior corneal epithelium. The anterior corneal epithelium also becomes fragile. This usually affects both eyes rather than a single eye and worsens over time. There are two phenotypes, Meesmann corneal dystrophy 1 (MECD1) and Meesmann corneal dystrophy 2 (MECD2), which affect the genes KRT3 and KRT12, respectively. A heterozygous mutation in either of these genes will lead to a single phenotype. Many with Meesmann corneal dystrophy are asymptomatic or experience mild symptoms.
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| rdf:type
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| rdfs:label
| - Meesmann-Hornhautdystrophie (de)
- Distrofia corneal de Meesmann (es)
- Distrofia di Meesmann (it)
- Meesmann corneal dystrophy (en)
- Дистрофия роговицы Месманна (ru)
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| rdfs:comment
| - Die Meesmann-Hornhautdystrophie (MECD) ist eine sehr seltene angeborene Form einer Hornhautdystrophie mit Krankheitsbeginn in frühester Kindheit. Synonyme sind: Hornhautdystrophie, epitheliale juvenile, Typ Meesmann; Meesmann-Epitheldystrophie der Hornhaut, juvenile hereditäre; Meesmann-Wilke-Syndrom; englisch Stocker-Holt dystrophy Die Bezeichnung bezieht sich auf den Autoren der Erstbeschreibung aus dem Jahre 1938 durch den Berliner Augenarzt Alois Meesmann (1888–1969). (de)
- La distrofia de Meesmann, también llamada distrofia epitelial juvenil hereditaria es una enfermedad hereditaria del ojo que se caracteriza por la aparición de pequeños quistes en la superficie de la córnea que se rompen hacia el exterior y provocan la aparición de erosiones corneales recidivantes. Esta entidad se clasifica dentro del grupo conocido como distrofias corneales que incluyen otros muchos procesos de carácter hereditario, como la distrofia endotelial de Fuchs.[cita requerida] (es)
- Meesmann corneal dystrophy (MECD) is a rare hereditary autosomal dominant disease that is characterized as a type of corneal dystrophy and a keratin disease. MECD is characterized by the formation of microcysts in the outermost layer of the cornea, known as the anterior corneal epithelium. The anterior corneal epithelium also becomes fragile. This usually affects both eyes rather than a single eye and worsens over time. There are two phenotypes, Meesmann corneal dystrophy 1 (MECD1) and Meesmann corneal dystrophy 2 (MECD2), which affect the genes KRT3 and KRT12, respectively. A heterozygous mutation in either of these genes will lead to a single phenotype. Many with Meesmann corneal dystrophy are asymptomatic or experience mild symptoms. (en)
- La distrofia di Meesmann (in sigla MECD) è una rara forma congenita di distrofia corneale che si manifesta fin dalla prima infanzia, caratterizzata da minuscole opacità, dovute a microcisti o vacuoli nell'epitelio corneale centrale e, in minore misura, nella cornea periferica, che hanno un limitato impatto sulla vista.Nelle persone con distrofia corneale di Meesmann, le cisti possono comparire già nel primo anno di vita. Di solito influenzano entrambi gli occhi e aumentano di numero nel tempo. Le cisti di solito non causano alcun sintomo fino alla tarda adolescenza o all'età adulta, quando iniziano a rompersi sulla superficie della cornea e causano irritazione. (it)
- Дистрофия роговицы Месманна (эпителиальная дистрофия роговицы) — редкая форма дистрофии роговицы, поражающая роговичный эпителий, в котором из-за мутаций генов KRT3 и KRT12, кодирующих кератин, возникают кисты. Из-за крайне малого размера мутных пятнышек, постепенно образующихся в толще эпителия, болезнь зачастую диагностируют, когда пациент достигает среднего возраста и начинает страдать от фотофобии и снижения зрения. В качестве терапии может быть использовано удаление эпителия, но оно не ведёт к окончательному излечению. (ru)
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| foaf:name
| - Meesmann Corneal Dystrophy (en)
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| name
| - Meesmann Corneal Dystrophy (en)
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| foaf:depiction
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| dcterms:subject
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| Wikipage page ID
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| Wikipage revision ID
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| Link from a Wikipage to another Wikipage
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| sameAs
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| types
| - Meesmann corneal dystrophy 1, Meesmann corneal dystrophy 2 (en)
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| thumbnail
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| diagnosis
| - Slit Lamp Biomicroscopy (en)
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| DiseasesDB
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| ICD
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| MeshID
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| OMIM
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| onset
| - Infancy or Young Childhood (en)
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| symptoms
| - Anterior corneal intraepithelial microcysts, Corneal erosions, Photophobia, Lacrimation, Intermittent visual, acuity loss , Nonprogressive corneal dystrophy, Fine punctate corneal opacities, Episodic foreign body sensation, Increased tear production, eye stinging, Blepharospasm (en)
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| treatment
| - Eye drops, Corneal Surgery (en)
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| caption
| - Multiple opaque spots in the corneal epithelium (en)
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| duration
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| field
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| synonyms
| - Meesmann Epithelial Corneal Dystrophy
Meesmann-Wilke Syndrome (en)
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| has abstract
| - Die Meesmann-Hornhautdystrophie (MECD) ist eine sehr seltene angeborene Form einer Hornhautdystrophie mit Krankheitsbeginn in frühester Kindheit. Synonyme sind: Hornhautdystrophie, epitheliale juvenile, Typ Meesmann; Meesmann-Epitheldystrophie der Hornhaut, juvenile hereditäre; Meesmann-Wilke-Syndrom; englisch Stocker-Holt dystrophy Die Bezeichnung bezieht sich auf den Autoren der Erstbeschreibung aus dem Jahre 1938 durch den Berliner Augenarzt Alois Meesmann (1888–1969). (de)
- La distrofia de Meesmann, también llamada distrofia epitelial juvenil hereditaria es una enfermedad hereditaria del ojo que se caracteriza por la aparición de pequeños quistes en la superficie de la córnea que se rompen hacia el exterior y provocan la aparición de erosiones corneales recidivantes. Esta entidad se clasifica dentro del grupo conocido como distrofias corneales que incluyen otros muchos procesos de carácter hereditario, como la distrofia endotelial de Fuchs.[cita requerida] (es)
- Meesmann corneal dystrophy (MECD) is a rare hereditary autosomal dominant disease that is characterized as a type of corneal dystrophy and a keratin disease. MECD is characterized by the formation of microcysts in the outermost layer of the cornea, known as the anterior corneal epithelium. The anterior corneal epithelium also becomes fragile. This usually affects both eyes rather than a single eye and worsens over time. There are two phenotypes, Meesmann corneal dystrophy 1 (MECD1) and Meesmann corneal dystrophy 2 (MECD2), which affect the genes KRT3 and KRT12, respectively. A heterozygous mutation in either of these genes will lead to a single phenotype. Many with Meesmann corneal dystrophy are asymptomatic or experience mild symptoms. It is named after the German ophthalmologist Alois Meesmann (1888-1969). It is often considered as the "Meesmann-Wilke syndrome", after the joint contribution of Meesmann and Wilke in 1939. Research was later contributed by Stocker and Holt in 1954 through 1955 who found a variant of Meesmann corneal dystrophy called "Stocker-Holt Dystrophy". (en)
- La distrofia di Meesmann (in sigla MECD) è una rara forma congenita di distrofia corneale che si manifesta fin dalla prima infanzia, caratterizzata da minuscole opacità, dovute a microcisti o vacuoli nell'epitelio corneale centrale e, in minore misura, nella cornea periferica, che hanno un limitato impatto sulla vista.Nelle persone con distrofia corneale di Meesmann, le cisti possono comparire già nel primo anno di vita. Di solito influenzano entrambi gli occhi e aumentano di numero nel tempo. Le cisti di solito non causano alcun sintomo fino alla tarda adolescenza o all'età adulta, quando iniziano a rompersi sulla superficie della cornea e causano irritazione. Prende il nome dall'oftalmologo Alois Meesmann che la descrisse nel 1938. Nel 1954 Frederick W. Stocker e L. Byerly Holt hanno pubblicato un rapporto su una distrofia a cui è stato attribuito il loro nome che è considerata però una variante della MECD. (it)
- Дистрофия роговицы Месманна (эпителиальная дистрофия роговицы) — редкая форма дистрофии роговицы, поражающая роговичный эпителий, в котором из-за мутаций генов KRT3 и KRT12, кодирующих кератин, возникают кисты. Из-за крайне малого размера мутных пятнышек, постепенно образующихся в толще эпителия, болезнь зачастую диагностируют, когда пациент достигает среднего возраста и начинает страдать от фотофобии и снижения зрения. В качестве терапии может быть использовано удаление эпителия, но оно не ведёт к окончательному излечению. Впервые заболевание было описано в 1939 году в Германии Месманном (1888-1969) и Вилке. (ru)
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