Mike O'Cain (born July 20, 1954) is an American football coach and former player. He was formerly the offensive coordinator and quarterbacks coach for the East Tennessee State University football team. He was the former offensive coordinator for James Madison and served as quarterbacks coach for the Virginia Tech Hokies football team, a position he had held from the 2006 season until the end of the 2012 season. O'Cain served as the head football coach at North Carolina State University from 1993 to 1999, compiling a record of 41–40. He played football as a quarterback and punter at Clemson University from 1974 to 1976.