Mississippi Highway 469 (MS 469) is a state highway in central Mississippi, located in Simpson and Rankin counties. The route starts at MS 28 near Georgetown, and it travels north through western Simpson County. The road enters the community of Harrisville and enters Rankin County soon after. It intersects U.S. Route 49 (US 49) in Florence, and it ends at MS 468 near Whitfield. The route was designated in 1953, and it was extended southwards to MS 20 (currently MS 28) in 1956. By 1960, all of the route was paved with asphalt.