Route 94 serves eastern and central Missouri. The entire route closely parallels the Missouri River. The eastern terminus is at U.S. Route 67 in West Alton; its western terminus is at the intersection of U.S. Route 54 and U.S. Route 63 in Jefferson City. Route 94 was one of the original 1922 highways, but its western terminus was in St. Charles at Route 2 (now U.S. Route 40) and Route 9 (now U.S. Route 61). US 40/61 are now part of Interstate 64, an important freeway in the area.