Mitchler Run is a tributary of Huntington Creek in Luzerne County, Pennsylvania, in the United States. It is approximately 1.9 miles (3.1 km) long and flows through Ross Township. The watershed of the stream has an area of 1.52 square miles (3.9 km2) and the stream has no named tributaries. The stream is considered by the Pennsylvania Fish and Boat Commission to be Class A Wild Trout Waters for brook trout.