Mpofu Nature Reserve is a nature reserve in the Amatole district of the Eastern Cape Province, South Africa that is managed by Eastern Cape Parks. Mpofu is situated roughly 25 km (16 miles) northwest of Fort Beaufort and 20 km (12 miles) west of Balfour. It lies on the escarpment and lower valleys of the Katberg Mountains and covers 7,500 ha (19,000 acres) with altitudes varying from 550 to 1,384 metres (1,804 to 4,541 ft). The reserve was established in 1985 from land purchased from families who were descended from the 1820 settlers.