Nathan Wetherell D.D. (1726–1808) was an academic administrator at the University of Oxford. He was Dean of Hereford, Master of University College, Oxford and Vice-Chancellor of Oxford University. Nathan Wetherell was originally from Durham. As Vice-Chancellor of Oxford, he set up the Oxford Paving Commission in 1771 to supervise paving, cleaning and lighting in the city of Oxford.He supported anti-Calvinism, along with David Durell and Thomas Randolph.Wetherell was a longtime friend of Samuel Johnson.