Sir Nicholas Wadham (by 1472–1542) was an English high sheriff, Royal Navy administrator and Member of Parliament. He was the grandfather of Wadham College, Oxford posthumous co-founder Nicholas Wadham (1531–1609). Sir Nicholas was Member of Parliament for Somerset as a Knight of the Shire with his kinsman Sir William Stourton, 7th Baron Stourton (c. 1505 – 1548), in the Reformation Parliament of 1529 to 1534.