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ORF7a (also known by several other names, including SARS coronavirus X4, SARS-X4, ORF7a, or U122) is a gene found in coronaviruses of the Betacoronavirus genus. It expresses the Betacoronavirus NS7A protein, a type I transmembrane protein with an immunoglobulin-like protein domain. It was first discovered in SARS-CoV, the virus that causes severe acute respiratory syndrome (SARS). The homolog in SARS-CoV-2, the virus that causes COVID-19, has about 85% sequence identity to the SARS-CoV protein.

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  • ORF7a (ar)
  • ORF7a (en)
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  • ORF7a (معروف كذلك بعدة أسماء منها SARS-X4 وU122‏) هو جين يوجد في جنس فيروس كورونا بيتا من فصيلة فيروسات كورونا. يُعبّر عن بروتين NS7A لفيروسات كورونا بيتا وهو بروتين عبر غشائي من الصنف 1 له نطاق مماثل . اكتُشف لأول مرة في سارس-كوف وهو الفيروس الذي يسبب المتلازمة التنفسية الحادة الوخيمة (السارس). يملك نديد هذا الجين في سارس-كوف-2 وهو الفيروس الذي يسبب كوفيد 19 تطابق تسلسل يقدر بحوالي 85% مقارنة بتسلسل سارس-كوف. (ar)
  • ORF7a (also known by several other names, including SARS coronavirus X4, SARS-X4, ORF7a, or U122) is a gene found in coronaviruses of the Betacoronavirus genus. It expresses the Betacoronavirus NS7A protein, a type I transmembrane protein with an immunoglobulin-like protein domain. It was first discovered in SARS-CoV, the virus that causes severe acute respiratory syndrome (SARS). The homolog in SARS-CoV-2, the virus that causes COVID-19, has about 85% sequence identity to the SARS-CoV protein. (en)
name
  • Betacoronavirus NS7A protein (en)
foaf:depiction
  • http://commons.wikimedia.org/wiki/Special:FilePath/7jtl_orf8_7ci3_orf7a_superposition.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/PDB_1xak_EBI.jpg
  • http://commons.wikimedia.org/wiki/Special:FilePath/SARS-CoV-2_genome.svg
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ucsc assembly
  • wuhCor1 (en)
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  • Structure of the SARS-coronavirus ORF7a accessory protein (en)
  • Genomic organisation of isolate Wuhan-Hu-1, the earliest sequenced sample of SARS-CoV-2, indicating the location of ORF7a (en)
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