Pascagoula station is a closed intercity train station in Pascagoula, Mississippi, United States. It originally the served the Louisville and Nashville Railroad but was most recently a stop for Amtrak. The station is on the National Register of Historic Places as the Louisville and Nashville Railroad Depot, and was designated a Mississippi Landmark by the Mississippi Department of Archives and History. In addition, the station serves as an art gallery owned by the Singing River Art Association.