Puerto Rico Highway 163 (PR-163) is a major two-way thoroughfare in Ponce, Puerto Rico. The road has both of its termini as well as all of its length entirely within the Ponce city limits. The road runs east to west from its eastern terminus at PR-2 in Barrio San Antón to its western terminus at PR-500 in Barrio Canas. The road has a length of 4.8 kilometers. Most of the road runs as part of Avenida Las Américas.