About: Ring chromosome 15

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Ring chromosome 15 (sometimes denoted as r15) is a condition that arises when chromosome 15 fuses to form a ring chromosome. Usually, ring chromosome 15 forms due to the modification or deletion of genetic information on chromosome 15 in the preliminary stages of embryonic development, but it can rarely also be inherited. Treatment for ring chromosome 15 predominantly targets the management of these symptoms rather than the chromosome ring itself.

Attributes	Values
rdf:type	Thing Disease disease
rdfs:label	كروموسوم حلقي 15 (ar) Ring chromosome 15 (en)
rdfs:comment	كروموسوم الحلقة (الصبغي) الذي يطلق عليه R15 هي حالة تظهر عندما يندمج كروموسوم R15 تكوين حلقة غالباََ R15 ينتج من خلال تعديلات أو حذف الجين على كروموسوم 15 في مراحل الأولية من التطور الجيني ولكن نادراََ ما يمكن توريثها. (ar) Ring chromosome 15 (sometimes denoted as r15) is a condition that arises when chromosome 15 fuses to form a ring chromosome. Usually, ring chromosome 15 forms due to the modification or deletion of genetic information on chromosome 15 in the preliminary stages of embryonic development, but it can rarely also be inherited. Treatment for ring chromosome 15 predominantly targets the management of these symptoms rather than the chromosome ring itself. (en)
name	Ring chromosome 15 (en)
foaf:depiction
dcterms:subject	Ring chromosomes Congenital disorders Rare diseases Syndromes
Wikipage page ID	60233857 (xsd:integer)
Wikipage revision ID	1109440053 (xsd:integer)
Link from a Wikipage to another Wikipage	Mosaic (genetics) Intrauterine growth restriction Cryptorchidism Genotype–phenotype distinction Brachydactyly Café au lait spot Centromere Chromosome Chromosome 15 Ring chromosomes Speech delay Congenital disorders Rare diseases Telomere Hypertelorism Syndromes Autosome Phenotype Physical therapy Speech–language pathology Growth chart Intellectual disability Microcephaly Occupational therapy Ultrasound Ring chromosome Sex chromosome P arm Triangular face Frontal bossing Supportive treatment Fetal ultrasonography Gene locus Growth deficiency Simian crease Genetic information Insulin-like growth factor I
sameAs	Ring chromosome 15 Ring chromosome 15 Ring chromosome 15
specialty	Medical genetics (en)
dbp:wikiPageUsesTemplate	dbt:Citation_needed dbt:Reflist dbt:Infobox_medical_condition
thumbnail	wiki-commons:Special:FilePath/NLM_ring_chromosome.jpg?width=300
synonym	Ring chromosome 15 syndrome, Ring 15 (en)
treatment	Supportive treatment
caption	Diagram of the formation of a ring chromosome (en)
causes	Deletion of genetic information from chromosome 15 (en)
duration	Lifelong (en)
frequency	Rare (en)
has abstract	كروموسوم الحلقة (الصبغي) الذي يطلق عليه R15 هي حالة تظهر عندما يندمج كروموسوم R15 تكوين حلقة غالباََ R15 ينتج من خلال تعديلات أو حذف الجين على كروموسوم 15 في مراحل الأولية من التطور الجيني ولكن نادراََ ما يمكن توريثها. إذا كانت نهاية اندماج الكروموسوم من دون نقصان المادة الوراثية يحتفظ الفرد بالنمط الظاهري الطبيعي مع تغير بسيط نسبياً، مع ذلك عندما يكون هناك حذف للماده الوراثية في الأطراف الغير مستقرة البعيدة حيث تندمج الهياكل الفرعية. تظهر متلازمات المرتبطة في تغير المادة الوراثية في هذا الكروموسوم. جميع الكروموسوم لديها القدرة على تكوين مثل هذه الحلقات الأعراض وشدة المتلازمة مرتبطة بكمية المعلومات الجينية المفقودة وبالتالي علاج هدف هاذ R15 يستهدف في الغالب القضاء على الأعراض بدل من القضاء على حلقة الكروموسوم نفسها. (ar) Ring chromosome 15 (sometimes denoted as r15) is a condition that arises when chromosome 15 fuses to form a ring chromosome. Usually, ring chromosome 15 forms due to the modification or deletion of genetic information on chromosome 15 in the preliminary stages of embryonic development, but it can rarely also be inherited. All chromosomes have the capacity to form ring chromosomes. The symptoms and severity largely depend on the amount and location of the genetic information lost. If the ends of the chromosome fuse with no loss of genetic material, the individual retains the normal phenotype with relatively slight differences. However, evidence suggests that when there is deletion of genetic information at the distal unstable ends where the subtelomeric structures fuse, syndromes associated with that particular chromosome arise. Treatment for ring chromosome 15 predominantly targets the management of these symptoms rather than the chromosome ring itself. (en)
prov:wasDerivedFrom	wikipedia-en:Ring_chromosome_15?oldid=1109440053&ns=0
page length (characters) of wiki page	13194 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Ring_chromosome_15
is Link from a Wikipage to another Wikipage of	Ring Chromosome 15 Ring chromosome R15
is Wikipage redirect of	Ring Chromosome 15
is foaf:primaryTopic of	wikipedia-en:Ring_chromosome_15

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