SOX genes (SRY-related HMG-box genes) encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box (for high mobility group). This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species. Homologues have been identified in insects, nematodes, amphibians, reptiles, birds and a range of mammals. However, HMG boxes can be very diverse in nature, with only a few amino acids being conserved between species.
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| - Protéines SOX (fr)
- SOX gene family (en)
- SOX基因家族 (zh)
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| rdfs:comment
| - Les protéines SOX sont un ensemble de facteurs de transcription qui jouent un rôle très important dans l’embryogenèse et dans la destinée des cellules non différenciées. Cette famille de protéines tire son nom de SRY (Sex determining Region on Y)-box. Cette famille a été nommée ainsi à cause du domaine HMG (High Mobility Group) qu’elle possède et qui est très semblable à celui de SRY, le gène codant la différenciation des gonades en testicules chez les embryons mâles. (fr)
- SOX基因家族（英語：SOX gene family，即SRY相关HMG盒基因家族，SRY-related HMG-box genes）是一类高速泳动族转录因子。 人类基因组拥有SRY等20个SOX家族成员，如下：
* SoxA: SRY
* SoxB1: , Sox2,
* SoxB2: ,
* SoxC: , ,
* SoxD: , ,
* SoxE: , SOX9,
* SoxF: , ,
* SoxG:
* SoxH: (zh)
- SOX genes (SRY-related HMG-box genes) encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box (for high mobility group). This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species. Homologues have been identified in insects, nematodes, amphibians, reptiles, birds and a range of mammals. However, HMG boxes can be very diverse in nature, with only a few amino acids being conserved between species. (en)
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| name
| - SOXB subfamily, C-terminal next to HMG box (en)
- SOXE, N-terminal (en)
- SOXF, C-terminal, 9aaTAD (en)
- SOXF, central (en)
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| InterPro
| - IPR021934 (en)
- IPR022097 (en)
- IPR022151 (en)
- IPR033392 (en)
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| Pfam
| - PF12067 (en)
- PF12336 (en)
- PF12444 (en)
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| symbol
| - SOX_C (en)
- SOXp (en)
- Sox17_18_mid (en)
- Sox_N (en)
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| - SOX genes (SRY-related HMG-box genes) encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box (for high mobility group). This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species. Homologues have been identified in insects, nematodes, amphibians, reptiles, birds and a range of mammals. However, HMG boxes can be very diverse in nature, with only a few amino acids being conserved between species. Sox genes are defined as containing the HMG box of a gene involved in sex determination called SRY, which resides on the Y-chromosome. There are 20 SOX genes present in humans and mice, and 8 present in Drosophila. Almost all Sox genes show at least 50% amino acid similarity with the HMG box in Sry. The family is divided into subgroups according to homology within the HMG domain and other structural motifs, as well as according to functional assays. The developmentally important Sox family has no singular function, and many members possess the ability to regulate several different aspects of development. While many Sox genes are involved in sex determination, some are also important in processes such as neuronal development. For example, Sox2 and Sox3 are involved in the transition of epithelial granule cells in the cerebellum to their migratory state. Sox 2 is also a transcription factor in the maintenance of pluripotency in both Early Embryos and ES Cells. Granule cells then differentiate to granule neurons, with Sox11 being involved in this process. It is thought that some Sox genes may be useful in the early diagnosis of childhood brain tumours due to this sequential expression in the cerebellum, making them a target for significant research. Sox proteins bind to the sequence WWCAAW and similar sequences (W=A or T). They have weak binding specificity and unusually low affinity for DNA. Sox genes are related to the Tcf/Lef1 group of genes which also contain a sequence-specific high mobility group and have a similar sequence specificity (roughly TWWCAAAG). (en)
- Les protéines SOX sont un ensemble de facteurs de transcription qui jouent un rôle très important dans l’embryogenèse et dans la destinée des cellules non différenciées. Cette famille de protéines tire son nom de SRY (Sex determining Region on Y)-box. Cette famille a été nommée ainsi à cause du domaine HMG (High Mobility Group) qu’elle possède et qui est très semblable à celui de SRY, le gène codant la différenciation des gonades en testicules chez les embryons mâles. (fr)
- SOX基因家族（英語：SOX gene family，即SRY相关HMG盒基因家族，SRY-related HMG-box genes）是一类高速泳动族转录因子。 人类基因组拥有SRY等20个SOX家族成员，如下：
* SoxA: SRY
* SoxB1: , Sox2,
* SoxB2: ,
* SoxC: , ,
* SoxD: , ,
* SoxE: , SOX9,
* SoxF: , ,
* SoxG:
* SoxH: (zh)
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| Symbol
| - SOX_C
- SOXp
- Sox17_18_mid
- Sox_N
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