Sam D. Hamilton Noxubee National Wildlife Refuge is a 48,000 acres (190 km2) National Wildlife Refuge located in the U.S. state of Mississippi, in Noxubee, Oktibbeha, and Winston Counties. The refuge serves as a resting and feeding area for migratory birds and as example of proper land stewardship. Also, the refuge extensively manages land for the endangered red-cockaded woodpecker.