Samuel Barry Guze (October 18, 1923 – July 19, 2000) was an American psychiatrist, medical educator, and researcher. A graduate of City College of New York and Washington University School of Medicine, he was an influential psychiatrist. He worked at the Washington University School of Medicine in St. Louis for most of his career. He was also among the first psychiatrists to study twins as a way to investigate the role of heredity in mental illness and contributed to the knowledge of genetic vulnerability to alcoholism and schizophrenia.
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