Señorita Panamá 2019 was the 53rd Señorita Panamá pageant. It selected the national representatives to the Miss Universe, Miss International, and Miss Grand International competitions. This was the fourth edition of the renewed Señorita Panama pageant, under the direction of Cesar Anel Rodríguez, who took charge of the national event in 2016. Twenty-four preliminary contestants were selected from throughout Panama and competed for the crown.