St. Francis Xavier College Church is a Catholic church in the Midtown neighborhood of St. Louis, Missouri, United States. The church was built by the Society of Jesus in 1836: the current building dates from 1884. It serves as a parish church in the Archdiocese of St. Louis and for the Saint Louis University community. It is a contributing property in the Midtown Historic District on the National Register of Historic Places and it is listed as a City Landmark in St. Louis.