St. Leo’s was a U.S. soccer team based in St. Louis, Missouri. It was founded in 1903 as a member of the St. Louis Association Football League before moving to the St. Louis Soccer League in 1908. It was one of the first fully professional soccer teams in the U.S. and dominated the St. Louis soccer scene for over a decade. In 1918, the team came under sponsorship of St. Louis Screw and competed under that name until 1922.