St Mary's Church is in Knowsley Lane, Knowsley Village, Merseyside, England. The church is recorded in the National Heritage List for England as a designated Grade II* listed building. It is an active Anglican parish church in the diocese of Liverpool, the archdeaconry of Liverpool and the deanery of Huyton. In the Buildings of England series, Pollard and Pevsner describe the church as being "largish" with "an intimate interior".