The translocase of the outer membrane (TOM) is a complex of proteins found in the outer mitochondrial membrane of the mitochondria. It allows movement of proteins through this barrier and into the intermembrane space of the mitochondrion. Most of the proteins needed for mitochondrial function are encoded by the nucleus of the cell. The outer membrane of the mitochondrion is impermeable to large molecules greater than 5000 Daltons. The TOM works in conjunction with the translocase of the inner membrane (TIM) to translocate proteins into the mitochondrion. Many of the proteins in the TOM complex, such as TOMM22, were first identified in Neurospora crassa and Saccharomyces cerevisiae. Many of the genes encoding these proteins are designated as TOMM (translocase of the outer mitochondrial memb
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| rdfs:label
| - Translocasa de la membrana externa (es)
- Translocase of the outer membrane (en)
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| rdfs:comment
| - La traslocasa de la membrana externa (TOM, siglas en inglés de translocase of the outer membrane) es un complejo proteico que se encuentra en la de la mitocondria. Su función es permitir el movimiento de proteínas a través de esta barrera y hacia el interior del . La mayoría de las proteínas que se necesitan en la función mitocondrial se codifican en el núcleo celular. La membrana externa de la mitocondria es impermeable a moléculas con un tamaño mayor de 5000 Daltons. El TOM (TIM) para traslocar proteínas al interior de la mitocondria. Muchas de las proteínas del complejo TOM, como TOMM22, fueron identificadas en primer lugar en Neurospora crassa y Saccharomyces cerevisiae. (es)
- The translocase of the outer membrane (TOM) is a complex of proteins found in the outer mitochondrial membrane of the mitochondria. It allows movement of proteins through this barrier and into the intermembrane space of the mitochondrion. Most of the proteins needed for mitochondrial function are encoded by the nucleus of the cell. The outer membrane of the mitochondrion is impermeable to large molecules greater than 5000 Daltons. The TOM works in conjunction with the translocase of the inner membrane (TIM) to translocate proteins into the mitochondrion. Many of the proteins in the TOM complex, such as TOMM22, were first identified in Neurospora crassa and Saccharomyces cerevisiae. Many of the genes encoding these proteins are designated as TOMM (translocase of the outer mitochondrial memb (en)
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| name
| - Mitochondrial import receptor subunit TOM20 (en)
- Mitochondrial import receptor subunit Tom22 (en)
- TOM7 family (en)
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| thumbnail
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| InterPro
| - IPR005683 (en)
- IPR010547 (en)
- IPR012621 (en)
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| Pfam
| - PF04281 (en)
- PF06552 (en)
- PF08038 (en)
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| symbol
| - Tom7 (en)
- TOM20_plant (en)
- Tom22 (en)
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| - La traslocasa de la membrana externa (TOM, siglas en inglés de translocase of the outer membrane) es un complejo proteico que se encuentra en la de la mitocondria. Su función es permitir el movimiento de proteínas a través de esta barrera y hacia el interior del . La mayoría de las proteínas que se necesitan en la función mitocondrial se codifican en el núcleo celular. La membrana externa de la mitocondria es impermeable a moléculas con un tamaño mayor de 5000 Daltons. El TOM (TIM) para traslocar proteínas al interior de la mitocondria. Muchas de las proteínas del complejo TOM, como TOMM22, fueron identificadas en primer lugar en Neurospora crassa y Saccharomyces cerevisiae. El complejo completo de proteín-traslocasa mitocondrial incluye al menos 19 proteínas: algunas chaperonas, cuatro proteínas del receptor de importación de la traslocasa de la membrata externa, cinco proteínas del complejo de canal Tom, cinco proteínas de la traslocasa de la membrana interna (Tim) y tres proteínas "motor". (es)
- The translocase of the outer membrane (TOM) is a complex of proteins found in the outer mitochondrial membrane of the mitochondria. It allows movement of proteins through this barrier and into the intermembrane space of the mitochondrion. Most of the proteins needed for mitochondrial function are encoded by the nucleus of the cell. The outer membrane of the mitochondrion is impermeable to large molecules greater than 5000 Daltons. The TOM works in conjunction with the translocase of the inner membrane (TIM) to translocate proteins into the mitochondrion. Many of the proteins in the TOM complex, such as TOMM22, were first identified in Neurospora crassa and Saccharomyces cerevisiae. Many of the genes encoding these proteins are designated as TOMM (translocase of the outer mitochondrial membrane) complex genes. The complete mitochondrial protein translocase complex includes at least 19 proteins: several chaperones, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the Tom channel complex, five proteins of the inner membrane translocase (Tim) and three "motor" proteins. (en)
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| Membranome superfamily
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| OPM family
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| OPM protein
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