U.S. Route 11 (US 11) roughly parallels Interstate 81 (I-81) in the U.S. state of Pennsylvania. The route runs from the Maryland state line in Antrim Township, Franklin County, northeast to the New York state line in Great Bend Township, Susquehanna County. US 11 serves Harrisburg, Wilkes-Barre, and Scranton. Between Harrisburg and Scranton, US 11 follows the Susquehanna River, while I-81 follows a shorter route over the mountains further to the east.