U.S. Route 13 Business (US 13 Business) is a business route of U.S. Route 13 in the U.S. state of Maryland. The highway runs 8.14 miles (13.10 km) between US 13 south of Fruitland and US 13 and US 50 on the north side of Salisbury. US 13 Business is a four-lane highway with divided and undivided sections that provides access to Salisbury University, downtown Salisbury, where the highway intersects US 50 Business, and Fruitland, where the highway meets MD 513. US 13 Business was constructed as a new alignment of US 13 in several steps in the 1930s and early 1940s. The section of the highway through Salisbury was originally constructed with four lanes, while the portion of the highway through Fruitland and at the northern end was expanded to a divided highway in the first half of the 1950s.