U.S. Route 25 (US 25) is a north–south United States highway that runs for 75.4 miles (121.3 km) from the South Carolina state line, near Tuxedo, to the Tennessee state line, near Hot Springs. It is part of the longer U.S. Route 25, which runs from Brunswick, Georgia to Covington, Ohio. It is a major north-south route through Western North Carolina.