U.S. Route 41 (US 41) in the state of Kentucky is a north-south United States Numbered Highway that mainly goes through the western part of the state. It enters Kentucky in the Todd County community of Guthrie, and leaves the state north of Henderson into Indiana as well as the city of Evansville. The total length of US 41 through Kentucky is a total of 106.952 miles (172.123 km).