About: U4 spliceosomal RNA

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The U4 small nuclear Ribo-Nucleic Acid (U4 snRNA) is a non-coding RNA component of the major or U2-dependent spliceosome – a eukaryotic molecular machine involved in the splicing of pre-messenger RNA (pre-mRNA). It forms a duplex with U6, and with each splicing round, it is displaced from the U6 snRNA (and the spliceosome) in an ATP-dependent manner, allowing U6 to re-fold and create the active site for splicing catalysis. A recycling process involving protein Brr2 releases U4 from U6, while protein Prp24 re-anneals U4 and U6. The crystal structure of a 5′ stem-loop of U4 in complex with a binding protein has been solved.

Attributes	Values
rdf:type	military unit
rdfs:label	U4 snRNA (ja) U4 spliceosomal RNA (en)
rdfs:comment	The U4 small nuclear Ribo-Nucleic Acid (U4 snRNA) is a non-coding RNA component of the major or U2-dependent spliceosome – a eukaryotic molecular machine involved in the splicing of pre-messenger RNA (pre-mRNA). It forms a duplex with U6, and with each splicing round, it is displaced from the U6 snRNA (and the spliceosome) in an ATP-dependent manner, allowing U6 to re-fold and create the active site for splicing catalysis. A recycling process involving protein Brr2 releases U4 from U6, while protein Prp24 re-anneals U4 and U6. The crystal structure of a 5′ stem-loop of U4 in complex with a binding protein has been solved. (en) U4 snRNA（U4 small nuclear RNA）は、メジャースプライソソーム（U2依存的スプライソソーム）のノンコーディングRNA構成要素である。スプライソソームは、真核生物のmRNA前駆体のスプライシングに関与する分子機械である。U4 snRNAはU6 snRNAと二重らせんを形成し、スプライシングのラウンドごとにATP依存的にU6 snRNA（そしてスプライソソーム）から除去される。U4 snRNAが除去されたU6 snRNAは再フォールディングし、スプライシングの触媒のための活性部位を形成する。U4のU6からの解離はによって行われ、U6との再アニーリングはによって行われる。U4の5'ステムループと結合タンパク質の複合体の結晶構造が解かれている。 (ja)
name	U4 spliceosomal RNA (en)
foaf:depiction
dcterms:subject	Small nuclear RNA RNA splicing Spliceosome
Wikipage page ID	11422378 (xsd:integer)
Wikipage revision ID	1032207606 (xsd:integer)
Link from a Wikipage to another Wikipage	NMR Prp24 MRNA RNA splicing Gene Crystal structure Small nuclear RNA Small nuclear RNA Active site U6 spliceosomal RNA Eukaryota Eukaryotic Stem-loop RNA splicing Spliceosome Sequence conservation X-ray crystallography Molecular machine Non-coding RNA SnRNP Spliceosome Secondary structure RNA structure probing RNAse
sameAs	U4 spliceosomal RNA U4 spliceosomal RNA U4 spliceosomal RNA U4 spliceosomal RNA
Tax domain	Eukaryota
dbp:wikiPageUsesTemplate	dbt:Cite_journal dbt:Refbegin dbt:Refend dbt:Reflist dbt:Short_description dbt:GO dbt:SO dbt:Infobox_rfam dbt:Rfam
thumbnail	wiki-commons:Special:FilePath/RF00015.jpg?width=300
caption	Predicted secondary structure and sequence conservation of U4 (en)
id	RF00015 (en)
symbol	U4 (en)
has abstract	The U4 small nuclear Ribo-Nucleic Acid (U4 snRNA) is a non-coding RNA component of the major or U2-dependent spliceosome – a eukaryotic molecular machine involved in the splicing of pre-messenger RNA (pre-mRNA). It forms a duplex with U6, and with each splicing round, it is displaced from the U6 snRNA (and the spliceosome) in an ATP-dependent manner, allowing U6 to re-fold and create the active site for splicing catalysis. A recycling process involving protein Brr2 releases U4 from U6, while protein Prp24 re-anneals U4 and U6. The crystal structure of a 5′ stem-loop of U4 in complex with a binding protein has been solved. (en) U4 snRNA（U4 small nuclear RNA）は、メジャースプライソソーム（U2依存的スプライソソーム）のノンコーディングRNA構成要素である。スプライソソームは、真核生物のmRNA前駆体のスプライシングに関与する分子機械である。U4 snRNAはU6 snRNAと二重らせんを形成し、スプライシングのラウンドごとにATP依存的にU6 snRNA（そしてスプライソソーム）から除去される。U4 snRNAが除去されたU6 snRNAは再フォールディングし、スプライシングの触媒のための活性部位を形成する。U4のU6からの解離はによって行われ、U6との再アニーリングはによって行われる。U4の5'ステムループと結合タンパク質の複合体の結晶構造が解かれている。 (ja)
Rfam	RF00015 (en)
RNA type	RNA splicing Gene Small nuclear RNA
gold:hypernym	Component
prov:wasDerivedFrom	wikipedia-en:U4_spliceosomal_RNA?oldid=1032207606&ns=0
page length (characters) of wiki page	14817 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:U4_spliceosomal_RNA
is Link from a Wikipage to another Wikipage of	Nucleic acid sequence RNA splicing Small Cajal body specific RNA 11 Small Cajal body specific RNA 13 Small Cajal body specific RNA 14 Small Cajal body specific RNA 15 Small Cajal body specific RNA 16 Small Cajal body specific RNA 17 Small Cajal body specific RNA 18 Small Cajal body specific RNA 20 Small Cajal body specific RNA 21 Small Cajal body specific RNA 23 Small Cajal body specific RNA 24 Small Cajal body specific RNA 4 Small Cajal body specific RNA 6 Small Cajal body specific RNA 8 Small nuclear RNA U11 spliceosomal RNA U4atac minor spliceosomal RNA U6 spliceosomal RNA Minor spliceosome Small Cajal body-specific RNA List of RNA structure prediction software Biomolecular structure SmY RNA PRPF31 U4 U4 snRNA
is Wikipage redirect of	U4 snRNA
is foaf:primaryTopic of	wikipedia-en:U4_spliceosomal_RNA

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