About: UDP-glucose 4-epimerase

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The enzyme UDP-glucose 4-epimerase (EC 5.1.3.2), also known as UDP-galactose 4-epimerase or GALE, is a homodimeric epimerase found in bacterial, fungal, plant, and mammalian cells. This enzyme performs the final step in the Leloir pathway of galactose metabolism, catalyzing the reversible conversion of UDP-galactose to UDP-glucose. GALE tightly binds nicotinamide adenine dinucleotide (NAD+), a co-factor required for catalytic activity.

Attributes	Values
rdf:type	Thing Biomolecule gene Biomolecule Gene yago:WikicatNADH-dependentEnzymes yago:Abstraction100002137 yago:Activator114723079 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Enzyme114732946 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 enzyme HumanGene yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatEnzymesOfKnownStructure
rdfs:label	UDP-Glucose-4-Epimerase (de) UDP-glucose 4-épimérase (fr) UDP-ガラクトース-4-エピメラーゼ (ja) UDP-glucose 4-epimerase (en)
rdfs:comment	UDP-Glucose-4-Epimerase (Gen: GALE), auch UDP-Galactose-4-Epimerase, ist das Enzym, das die Umlagerung von zu UDP-Glucose und umgekehrt katalysiert. Diese Reaktion ist ein Teilschritt in der Verwertung von Galactose in vielen Lebewesen. Mutationen im GALE-Gen können zum Mangel an Epimerase und dieser zu Galaktosämie Typ 3 führen. (de) L'UDP-glucose 4-épimérase, ou UDP-galactose 4-épimérase (GALE), est une épimérase homodimérique présente chez les bactéries, les mycètes, les plantes et les mammifères, qui catalyse la réaction : UDP-glucose UDP-galactose. Cette enzyme intervient à l'étape finale de la voie de Leloir de dégradation du galactose. Elle requiert du NAD+ comme cofacteur. Chez l'homme et chez certaines bactéries, cette enzyme est également capable d'agir sur l'UDP-N-acétylglucosamine pour former de l' en présence de NAD+, étape initiale de la biosynthèse de glycoprotéines et de glycolipides. (fr) UDP-ガラクトース-4-エピメラーゼ（英：UDP-galactose-4-epimerase、GALE、EC 5.1.3.2）またはUDP-グルコース-4-エピメラーゼは、ガラクトース血症のタイプ3に関連する酵素である。この酵素はUDP-グルコースをUDP-ガラクトースへ転換する。 (ja) The enzyme UDP-glucose 4-epimerase (EC 5.1.3.2), also known as UDP-galactose 4-epimerase or GALE, is a homodimeric epimerase found in bacterial, fungal, plant, and mammalian cells. This enzyme performs the final step in the Leloir pathway of galactose metabolism, catalyzing the reversible conversion of UDP-galactose to UDP-glucose. GALE tightly binds nicotinamide adenine dinucleotide (NAD+), a co-factor required for catalytic activity. (en)
name	UDP-glucose 4-epimerase (en) NAD-dependent epimerase/dehydratase (en) UDP-galactose-4-epimerase (en)
foaf:depiction
dct:subject	Enzymes of known structure NADH-dependent enzymes EC 5.1.3
Wikipage page ID	14217864 (xsd:integer)
Wikipage revision ID	1096302776 (xsd:integer)
Link from a Wikipage to another Wikipage	Rossmann fold Nobel Prize in Chemistry Inositol-3-phosphate synthase Galactose mutarotase Enzymes of known structure NADH-dependent enzymes Enzyme dbr:Galactose Galactosemia Glycolysis Active site Escherichia coli Nicotinamide adenine dinucleotide Glycolipid Glycoprotein Leloir pathway EC 5.1.3 Phosphoglucomutase Glycosyltransferases Inositol UDP-GlcNAc Galactose-1-phosphate Galactose-1-phosphate uridyltransferase Luis Leloir Glucose-1-phosphate Glucose-6-phosphate Inositol-1-phosphate UDP-galactose UDP-glucose
Link from a Wikipage to an external page	https://www.ncbi.nlm.nih.gov/books/NBK51671/ https://www.ncbi.nlm.nih.gov/omim/230350,606953,230350,606953 https://www.ncbi.nlm.nih.gov/protein/YP_701629.1 https://www.ncbi.nlm.nih.gov/protein/ZP_05580029.1
sameAs	UDP-glucose 4-epimerase UDP-glucose 4-epimerase UDP-glucose 4-epimerase UDP-glucose 4-epimerase UDP-glucose 4-epimerase UDP-glucose 4-epimerase UDP-glucose 4-epimerase UDP-glucose 4-epimerase UDP-glucose 4-epimerase UDP-glucose 4-epimerase UDP-glucose 4-epimerase UDP-glucose 4-epimerase UDP-glucose 4-epimerase
dbp:wikiPageUsesTemplate	dbt:Cite_book dbt:Cite_journal dbt:EnzExplorer dbt:Enzyme dbt:Enzymes dbt:Infobox_gene dbt:Main

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