The former U.S. Post Office in Canandaigua, New York, is located on North Main Street (New York state routes 21 and 332). It is a Classical Revival granite structure built in 1910 and expanded in 1938. It was listed on the National Register of Historic Places both as a contributing property to the Canandaigua Historic District in 1984 and individually in 1988, as part of a Multiple Property Submission of over 200 post offices all over the state.