State Trunk Highway 22 (often called Highway 22, STH-22 or WIS 22) is a state highway in the U.S. state of Wisconsin. The route's trajectory is mostly south to north, with the exception of the segment between Shawano and the northern terminus being east–west. It is generally a two-lane surface road providing a connecting route between Waupaca, Shawano, Gillett and Oconto. Various urban sections have multilane segments.