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Cambridge is a city in and the county seat of Guernsey County, Ohio, United States. It lies in southeastern Ohio, in the Appalachian Plateau of the Appalachian Mountains 74 miles east of Columbus. The population was 10,635 at the 2010 census. It is the principal city of the Cambridge Micropolitan Statistical Area and is located adjacent to the intersection of Interstates 70 and 77.