The 1950 Wilkes 200 was a NASCAR Grand National Series event that was held on September 24, 1950, at North Wilkesboro Speedway in North Wilkesboro, North Carolina. Due to the mostly informal nature of the NASCAR organization during the early 1950s, certain records like the number of laps completed under a caution flag and the amount of time it took to complete the race were never placed in the league's archives. Lee Petty, Lloyd Moore and Dick Linder mathematically eliminated themselves from the championship by not taking part in this race.