The 2010–11 Amlin Challenge Cup was the 15th season of the European Challenge Cup, Europe's second-tier club rugby union competition, and the second to be sponsored by the British insurance company Amlin. The tournament began on 7 October 2010, with the final played on 20 May 2011 at Cardiff City Stadium, the day before the 2011 Heineken Cup Final in the same city at Millennium Stadium. A total of 23 teams from six countries participated. The competition began with 20 teams; three more teams that began their seasons in the Heineken Cup parachuted into the knockout stage. Cardiff Blues did not defend their title, as by winning the 2009–10 cup, they qualified for the 2010–11 Heineken Cup, and did not parachute into the Challenge Cup.