The 2010 African Women's Handball Cup Winners' Cup was the 26th edition, organized by the African Handball Confederation, under the auspices of the International Handball Federation, the handball sport governing body. The tournament was held from April 7–17, 2010, at the in Ouagadougou, Burkina Faso, contested by 8 teams and won by Atlético Petróleos de Luanda of Angola.