The 2010 Central Oklahoma Bronchos football team represented the University of Central Oklahoma in the 2010 NCAA Division II football season, the 105th season of Broncho football. The team was led by fourth year head coach Tracy Holland. They played their home games at Wantland Stadium in Edmond, Oklahoma. The Bronchos were playing this season in their final year of membership in the Lone Star Conference, because they were changing conference affiliation to the Mid-America Intercollegiate Athletics Association.