The 2016 Saint Louis FC season was the franchise's second season in the United Soccer League, the third division of soccer in the United States. After playing their first season in the Eastern Conference of the USL, due to the addition of new teams to the league the club moved to the Western Conference for 2016. The club also renewed their affiliation with the Chicago Fire of Major League Soccer for the 2016 season, having partnered with them the previous year.